RESEARCH

Research at Brown University

Third year Biomedical Engineering Ph.D. Candidate at Brown University. Adriana joined the Tripathi Biomedical Engineering Group in 2020, where her research focuses on the development of miniaturized/microfluidic techniques to analyze and characterize biopharmaceuticals (AAV, LNP, mRNA vaccines) and screen for diseases (breast cancer, aneuploidy). Prior to joining Brown, she completed an M.S. in Science, Technology and Public Policy, a B.S. in Biomedical Engineering, and a B.S. in Biotechnology and Molecular Biosciences.

Journal Articles

Aibel, C.^†; Coll De Peña, A.^†; Tripathi, A. An Optimized CoBRA Method for the Microfluidic Electrophoresis Detection of Breast Cancer Associated RASSF1 Methylation. BioTech, 2023, 12(1), 7. ^†Co-first authors, contributed equally.
Coll De Peña, A.; Masto, L.; Atwood, J.; Tripathi, A. Electrophoresis-Mediated Characterization of Full and Empty Adeno-Associated Virus Capsids. ACS Omega 2022, 7 (27), 23457-23466.
Hill, N.; Coll De Peña, A.; Miller, A.; Lapizco-Encinas, B.H. On the potential of microscale electrokinetic cascade devices. Electrophoresis 2021.
Antunez-Vela, S.; Perez-Gonzalez, V.H.; Coll De Peña, A.; Lentz, C.J.; Lapizco-Encinas, B.H. Simultaneous Determination of Linear and Nonlinear Electrophoretic Mobilities of Cells and Microparticles. Analytical Chemistry 2020.
Coll De Peña, A.; Hill, N.; Lapizco-Encinas, B.H. Determination of the Empirical Electrokinetic Equilibrium Condition of Microorganisms in Microfluidic Devices. Biosensors 2020, 10, 148.
Quevedo, D. F.; Lentz, C. J.; Coll de Peña, A.; Hernandez, Y.; Habibi, N.; Miki, R.; Lahann, J.; Lapizco-Encinas, B. H. Electrokinetic characterization of synthetic protein nanoparticles. Beilstein J. Nanotechnol. 2020, 11, 1556–1567.
Coll De Peña, A.; Miller, A.; Lentz, C.J.; Hill, N.; Parthasarathy, A.; Hudson, A.O.; Lapizco-Encinas, B.H. Creation of an electrokinetic characterization library for the detection and identification of biological cells. Anal. Bioanal. Chem. 2020, 412, 3935–3945.
Coll De Peña, A.; Mohd Redzuan, N.H.; Abajorga, M.K; Hill, N.; Thomas, J.A.;* Lapizco-Encinas, B.H.* Analysis of Bacteriophages with Insulator-Based Dielectrophoresis, Micromachines, 10(7) 450, 2019.
Thomas, J.A.; Benítez Quintana, A.D.; Bosch, M.A.; Coll De Peña, A.; Aguilera, E.; Coulibaly, A.; Wu, W.; Osier, M.V.; Hudson, A.O.; Weintraub, S.T.; et al. Identification of essential genes in the Salmonella phage SPN3US reveals novel insights into giant phage head structure and assembly. J. Virol. 2016, 90, 10284–10298.

Conference Presentations

Coll De Peña, A.; Chen, N.; Gutterman-Johns, E.; Zimmer, D.; Bailey-Hytholt, C.; Tripathi, A. High Throughput Microfluidic Purity Assessment Method for Gene Therapies, SLAS 2023 International Conference, San Diego, CA, 02/23.
Coll De Peña, A.; Tripathi, A. Microfluidic Electrophoretic Characterization of Full and Empty Adeno-Associated Virus Capsids. Exploring Characterization Methods: How to Completely Characterize Empty & Full Virus Particles Workshop, Gene Therapy Analytical Development Summit, Boston, MA, 11/22. Workshop speakers and panelists: Coll De Peña, A.; Draper, B.; Bechill, J.; Katsikis, G.; Wang, W.
Coll De Peña, A.; Tripathi, A. Electrophoresis-Mediated Characterization of Full and Empty Adeno-Associated Virus Capsids, The 2022 SACNAS National Diversity in STEM Conference, San Juan, Puerto Rico 10/2022.
Coll De Peña, A.; Aibel, C.; Tripathi, A. Microfluidic electrophoresis detection of breast cancer associated RASSF1 methylation, Recent Advances in Biomedical Diagnostic Platforms Workshop, Institute of Medical Sciences in Mongolia (Online), 09/2022.
Li, N.; Coll De Peña, A.; Vaduva, M.; Tripathi, A.; Detection and Characterization of dsRNA contaminant in mRNA vaccines using microfluidic electrophoresis, Research Symposium at Brown University, Providence, RI, 08/2022.
Coll De Peña, A.; Tripathi. A. Microfluidic electrophoresis mediated characterization of Adeno-Associated Virus purity, New England Regional SACNAS Meeting, Providence RI, 06/2022.
Coll De Peña, A.; Masto, L.; Tripathi. A. Microfluidic electrophoretic assessment of Adeno-Associated Virus purity, PEGS Boston, Boston MA, 5/2022.
Coll De Peña, A.; Masto, L.; Tripathi, A. Microfluidic Electrophoresis-Based Assessment of Adeno-Associated Virus Purity in Terms of Full and Empty Capsids, PEGS Boston, Boston MA, 05/2022.
Coll De Peña, A.; Tripathi, A. Biomedical Engineering and Microfluidics at Virtual Annual Research Week, Universidad Nacional Pedro Henríquez Ureña, Dominican Republic (online), 07/2021.
Antunez-Vela, S.; Perez-Gonzalez, V.H.; Coll De Peña, A.; Lentz, C.J.; Lapizco-Encinas, B.H.* Characterizing unusual particle electromigration effects in a straight PDMS channel at SciX 2020 Virtual Meeting, 10/2020.
Miller, A.; Hill, N.; Coll De Peña, A.; Lapizco-Encinas, B.H. Electrokinetic separation of cells and polystyrene particles in an insulator-based device, Annual AES Meeting at SciX 2020 Virtual Meeting, 10/2020.
Hill, N.; Coll De Peña, A.; Miller, A.; Lapizco-Encinas, B.H.; Microparticle filtration and separation using cascade devices, Annual AES Meeting at SciX 2020 Virtual Meeting, 10/2020.
Coll De Peña, A.; Mohd Redzuan, N.H.; Abajorga, M.K; Hill, N.; Thomas, J.A.;* Lapizco-Encinas, B.H.* Electrokinetic assessment of bacteriophage virus. 2019 AES Annual meeting at Scix, Palm Springs CA, 10/2019.
Coll De Peña, A.; Parthasarathy, A.; Hudson, A.O.; Lapizco-Encinas, B.H.* Insulator-based dielectrophoresis to characterize the electrokinetic behavior of bacterial and yeast cells and create a library, 2019 AES Annual meeting at Scix, Palm Springs CA, 10/2019.
Coll De Peña, A.; Hill, N.; Lapizco-Encinas, B.H.* Multi-stage electrokinetic microsystem for the purification and assessment of microbes, 2019 AES Annual meeting at Scix, Palm Springs CA, 10/2019.
Hill, N.; Coll De Peña, A.; Lapizco-Encinas, B.H.* Multi-stage electrokinetic microsystem for the purification and assessment of microbes, 2019 AES Annual meeting at Scix, Palm Springs CA, 10/2019.
Coll De Peña, A.; Mohd Redzuan, N.H.; Thomas, J.A.; Lapizco-Encinas, B.H.;* Insulator-based dielectrophoresis to purify and enrich bacteriophages, Annual AES Meeting @ Scix, Atlanta GA, 10/2018.
Coll De Peña, A.; Parthasarathy, A.; Hudson, A.O.; Lapizco-Encinas, B.H.;* Insulator-based dielectrophoresis to characterize the electrokinetic behavior of bacterial cells and create a library, Annual AES Meeting @ Scix, Atlanta GA, 10/2018.
Weintraub, S.T., Coll, A., Bosch, M., Hajala, K., Pardo, S., Molleur, D., Hardies, S. C., Black, L. W. and Thomas, J.A. ‘Novel Genetic Determinants for Complex Head Composition in a Giant Salmonella Phage’; American Society for Mass Spectrometry Annual Conference, San Antonio, Texas, USA; 06/2016.
Thomas, J.A., Coll, A., Bosch, M., Adams, L., Benitez, D., Aguilera, E., Coulibaly, A., Cheng, N., Wu, W., Steven, A.C.,Weintraub,S.T., Hardies, S.C. and Black, L.W. ‘Exploiting Mutational Surrogacy to Study Head Morphogenesis of Giant PhiKZ-related Phages’; Evergreen International Phage Meeting, Evergreen State College, Olympia, Washington, USA; 10/2015

Previous Research Laboratories

Lapizco Laboratory (Microscale Bioseparation Research) at the Rochester Institute of Technology, 08/2017-05/2020

Hudson Laboratory (Plant Biotechnology Reseach) at the Rochester Institute of Technology, 08/2016-08/2017

Thomas Laboratory (Bacteriophage Research) at the Rochester Institute of Technology, 08/2014-05/2016

Penninger Laboratory (Cancer Research) at the Institute of Molecular Biotechnology of Austria, Summers 2014 and 2015